Beruflicher Werdegang

Niedergelassener Neurologe

Seit Jan. 2024
Schwerpunktpraxis Kopfschmerz, Klenzestr. 67

Juli 2023 - Dez. 2023
Schwerpunktpraxis Kopfschmerz, Leopoldstr. 175

Jan. 2011 - Juni 2023
Neurologie und Kopfschmerzzentrum Münchner Freiheit, Gemeinschaftspraxis


Sept. 2011 – Aug. 2017
Kollegialer Leiter des Algesiologikums - Zentrum für Schmerzmedizin, Schwabing, Clinic Dr. Decker GmbH

W3-Professur für Schmerz- u. Kopfschmerzforschung

April 2007 – Dez. 2010
Abteilung für Neurologie und Neurophysiologie Uniklinik, Freiburg und Ärztlicher Leiter Interdisziplinäres Schmerzzentrum, Uniklinik Freiburg

Chair of Neurology

Nov. 2006 – März 2007
Division of Clinical Neurosciences, School of Medicine, Southampton University and Southampton General Hospital, Southampton, UK

Honorary Consultant & Senior Lecturer

Mai 1999 – Okt. 2006
Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, UK


Feb. 1993 - April 1999
Klinik und Poliklinik für Neurologie, Director: Prof HC Diener Universitätsklinik Essen


Studium Humanmedizin 1982 – 1988: Technische Universität München
Ärztliche Approbation: 6.12.1990


BVDN (Bundesverband Deutscher Nervenärzte)

BDN (Bundesverband Deutscher Neurologen)

BVDP (Bundesverband Deutscher Psychiater)

Deutsche Schmerzgesellschaft


  1. Obermann, M., Nägel, S., Ose, C., Sonuc, N., Scherag, A., Storch, P., Gaul, C., Böger, A., Kraya, T., Jansen, J.-P., et al. (2021). Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial. The Lancet Neurology 20 .
  2. Simshäuser, K., Lüking, M., Kaube, H., Schultz, C., and Schmidt, S. (2020). Is Mindfulness-Based Stress Reduction a Promising and Feasible Intervention for Patients Suffering from Migraine? A Randomized Controlled Pilot Trial. Complementary Medicine Research 27 .
  3. Marin, J.C.A., Gantenbein, A.R., Paemeleire, K., Kaube, H., and Goadsby, P.J. (2015). Nociception-specific blink reflex: pharmacology in healthy volunteers. Journal of Headache and Pain 16 .
  4. Gantenbein, A.R., Sandor, P.S., Goadsby, P.J., and Kaube, H. (2014). Chirp stimulation: H-response short and dynamic. Cephalalgia 34 .
  5. Afridi, S.K., Giffin, N.J., Kaube, H., and Goadsby, P.J. (2013). A randomized controlled trial of intranasal ketamine in migraine with prolonged aura. Neurology 80 .
  6. Gantenbein, A.R., Sandor, P.S., Fritschy, J., Turner, R., Goadsby, P.J., and Kaube, H. (2013). Sensory information processing may be neuroenergetically more demanding in migraine patients. NeuroReport 24 .
  7. Wolter, T., and Kaube, H. (2013). Spinal cord stimulation in cluster headache.
  8. Holle, D., Gaul, C., Zillessen, S., Naegel, S., Krebs, S., Diener, H.-C., Kaube, H., Katsarava, Z., and Obermann, M. (2012). Lateralized central facilitation of trigeminal nociception in cluster headache. Neurology 78 .
  9. Hornyak, M., and Kaube, H. (2012). Clinical/scientific notes. Neurology 79 .
  10. Reinhard, M., Schork, J., Allignol, A., Weiller, C., and Kaube, H. (2012). Cerebellar and cerebral autoregulation in migraine. Stroke 43 .
  11. Schmidt, S., Naranjo, J.R., Brenneisen, C., Gundlach, J., Schultz, C., Kaube, H., Hinterberger, T., and Jeanmonod, D. (2012). Pain ratings, psychological functioning and quantitative EEG in a controlled study of chronic back pain patients. PLoS ONE 7 .
  12. Wolter, T., and Kaube, H. (2012). Neurostimulation for chronic cluster headache. Therapeutic Advances in Neurological Disorders 5 .
  13. Holle, D., Gaul, C., Krebs, S., Naegel, S., Diener, H.-C., Kaube, H., Katsarava, Z., and Obermann, M. (2011). Nociceptive blink reflex and pain-related evoked potentials in hypnic headache. Cephalalgia 31 .
  14. Wolter, T., Kiemen, A., and Kaube, H. (2011). High cervical spinal cord stimulation for chronic cluster headache. Cephalalgia 31 .
  15. Mueller, D., Obermann, M., Koeppen, S., Kavuk, I., Yoon, M.-S., Sack, F., Diener, H.-C., Kaube, H., and Katsarava, Z. (2010). Electrically evoked nociceptive potentials for early detection of diabetic small-fiber neuropathy. European Journal of Neurology 17 .
  16. Weatherall, M.W., Telzerow, A.J., Cittadini, E., Kaube, H., and Goadsby, P.J. (2010). Intravenous aspirin (lysine acetylsalicylate) in the inpatient management of headache. Neurology 75 .
  17. Weiller, C., and Kaube, H. (2010). Authors’ reply. Cephalalgia 30 .
  18. Magis, D., Bendtsen, L., Goadsby, P.J., May, A., Rio, M.S.D., Sandór, P.S., Kaube, H., Sandrini, G., Schoonman, G.G., and Schoenen, J. (2009). Erratum: Afridi S. Evaluation and proposal for optimization of neurophysiological tests in migrane: Part 2-neuroimaging and the nitroglycerin test. (Cephalalgia (2007) 27 (1339-1359)). Cephalalgia 29 .
  19. Obermann, M., Pleger, B., de Greiff, A., Stude, P., Kaube, H., Diener, H.-C., and Katsarava, Z. (2009). Temporal summation of trigeminal pain in human anterior cingulate cortex. NeuroImage 46 .
  20. Artemenko, A.R., Kurenkov, A.L., Filatova, E.G., Nikitin, S.S., Kaube, H., and Katsarava, Z. (2008). Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine. Cephalalgia 28 .
  21. Kaube, H., Aicher, B., Haag, G., and Fiebich, B.L. (2008). Treatment of headache with first choice drugs: Combination analgesics from acetylsalicylic acid, paracetamol and caffeine. Pharmazeutische Zeitung 153 .
  22. Obermann, M., Katsarava, Z., Esser, S., Sommer, C., He, L., Selter, L., Yoon, M.-S., Kaube, H., Diener, H.-C., and Maschke, M. (2008). Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy. Pain 138 .
  23. Wolter, T., Kaube, H., and Mohadjer, M. (2008). High cervical epidural neurostimulation for cluster headache: Case report and review of the literature. Cephalalgia 28 .
  24. Busch, V., Jakob, W., Juergens, T., Schulte-Mattler, W., Kaube, H., and May, A. (2007). Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Cephalalgia 27 .
  25. Dzagnidze, A., Katsarava, Z., Makhalova, J., Liedert, B., Yoon, M.-S., Kaube, H., Limmroth, V., and Thomale, J. (2007). Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy. Journal of Neuroscience 27 .
  26. Magis, D., Bendtsen, L., Goadsby, P.J., May, A., Rio, M.S.D., Sandór, P.S., Kaube, H., Sandrini, G., Schoonman, G.G., and Schoenen, J. (2007). Evaluation and proposal for optimization of neurophysiological tests in migraine: Part 2 - Neuroimaging and the nitroglycerin test. Cephalalgia 27 .
  27. Obermann, M., Yoon, M.-S., Ese, D., Maschke, M., Kaube, H., Diener, H.-C., and Katsarava, Z. (2007). Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia. Neurology 69 .
  28. Ayzenberg, I., Obermann, M., Nyhuis, P., Gastpar, M., Limmroth, V., Diener, H.C., Kaube, H., and Katsarava, Z. (2006). Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia 26 .
  29. Baad-Hansen, L., List, T., Kaube, H., Jensen, T.S., and Svensson, P. (2006). Blink reflexes in patients with atypical odontalgia and matched healthy controls. Experimental Brain Research 172 .
  30. Busch, V., Jakob, W., Juergens, T., Schulte-Mattler, W., Kaube, H., and May, A. (2006). Functional connectivity between trigeminal and occipital nerves revealed by occipital nerve blockade and nociceptive blink reflexes. Cephalalgia 26 .
  31. Katsarava, Z., Ayzenberg, I., Sack, F., Limmroth, V., Diener, H.-C., and Kaube, H. (2006). A novel method of eliciting pain-related potentials by transcutaneous electrical stimulation. Headache 46 .
  32. Paemeleire, K., Crevits, L., Goadsby, P.J., and Kaube, H. (2006). Practical management of medication-overuse headache. Acta Neurologica Belgica 106 .
  33. Rejdak, K., Empl, M., Giffin, N.J., Afridi, S.K., Petzold, A., Stelmasiak, Z., Thompson, E.J., Goadsby, P.J., Kaube, H., and Giovannoni, G. (2006). Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients. European Journal of Neurology 13 .
  34. Sandor, P.S., Irimia, P., Jager, H.R., Goadsby, P.J., and Kaube, H. (2006). Onset of cluster headache triggered by emotional effect: A case report [5]. Journal of Neurology, Neurosurgery and Psychiatry 77 .
  35. Sándor, P.S., Morath, G.P., Hess, K., Kaube, H., Agosti, R.M., and Regard, M. (2006). Prosopagnosia as symptom of migraine with aura: A case report. Cephalalgia 26 .
  36. Afridi, S.K., Matharu, M.S., Lee, L., Kaube, H., Friston, K.J., Frackowiak, R.S.J., and Goadsby, P.J. (2005). A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 128 .
  37. Cohen, A.S., and Kaube, H. (2005). Primary headache disorders and circadian biology: A clinical, imaging, and therapy perspective. Headache Currents 2 .
  38. Afridi, S.K., Kaube, H., and Goadsby, P.J. (2004). Glyceryl trinitrate triggers premonitory symptoms in migraineurs. Pain 110 .
  39. Akerman, S., Kaube, H., and Goadsby, P.J. (2004). Anandamide Is Able to Inhibit Trigeminal Neurons Using an in Vivo Model of Trigeminovascular-Mediated Nociception. Journal of Pharmacology and Experimental Therapeutics 309 .
  40. Cohen, A.S., and Kaube, H. (2004). Rare nocturnal headaches. Current Opinion in Neurology 17 .
  41. Giffin, N.J., Katsarava, Z., Pfundstein, A., Ellrich, J., and Kaube, H. (2004). The effect of multiple stimuli on the modulation of the “nociceptive” blink reflex. Pain 108 .
  42. Gil-Gouveia, R., Wilkinson, P.A., and Kaube, H. (2004). Severe hemiplegic migraine attack precipitated by fentanyl sedation for esophagogastroscopy. Neurology 63 .
  43. Katsarava, Z., Limmroth, V., Baykal, O., Akguen, D., Diener, H.-C., and Kaube, H. (2004). Differences of anti-nociceptive mechanisms of migraine drugs on the trigeminal pain processing during and outside acute migraine attacks. Cephalalgia 24 .
  44. Singer, T., Seymour, B., O’Doherty, J., Kaube, H., Dolan, R.J., and Frith, C.D. (2004). Empathy for Pain Involves the Affective but not Sensory Components of Pain. Science 303 .
  45. Akerman, S., Kaube, H., and Goadsby, P.J. (2003). Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation. British Journal of Pharmacology 140 .
  46. Giffin, N.J., Kowacs, F., Libri, V., Williams, P., Goadsby, P.J., and Kaube, H. (2003). Effect of the adenosine A<inf>1</inf> receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalalgia 23 .
  47. Katsarava, Z., Egelhof, T., Kaube, H., Diener, H.-C., and Limmroth, V. (2003). Symptomatic migraine and sensitization of trigeminal nociception associated with contralateral pontine cavernoma. Pain 105 .
  48. Kowacs, F., Giffin, N.J., Putzki, N., Goadsby, P.J., and Kaube, H. (2003). Nociceptive-specific blink reflex and glyceryl trinitrate infusion in healthy volunteers. European Journal of Neurology 10 .
  49. Akerman, S., Williamson, D.J., Kaube, H., and Goadsby, P.J. (2002). Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels. British Journal of Pharmacology 137 .
  50. Giffin, N.J., and Kaube, H. (2002). The electrophysiology of migraine. Current Opinion in Neurology 15 .
  51. Katsarava, Z., Frings, M., Kaube, H., Diener, H.C., and Limmroth, V. (2002). Selective damage of trigeminal Aδ fibres in Raeder’s syndrome following dissection of the ICA detected by a nociceptive blink reflex [3]. Cephalalgia 22 .
  52. Kaube, H., Katsarava, Z., Przywara, S., Drepper, J., Ellrich, J., and Diener, H.-C. (2002). Acute migraine headache: Possible ensitization of neurons in the spinal trigeminal nucleus? Neurology 58 .
  53. Knight, Y.E., Bartsch, T., Kaube, H., and Goadsby, P.J. (2002). P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 22 .
  54. Ellrich, J., Katsarava, Z., Przywara, S., and Kaube, H. (2001). Is the R3 component of the human blink reflex nociceptive in origin? Pain 91 .
  55. Diener, H.C., Kaube, H., and Limmroth, V. (2000). Migraine: Clinical aspects, diagnosis and drug therapy. Internist 41 .
  56. Kaube, H., Mummel, P., and Koeppen, S. (2000). Ethambutol related headache in HIV infection: Sensitisation to normal CSF pressure? A case report. Journal of Neurology Neurosurgery and Psychiatry 68 .
  57. Diener, H.C., Kaube, H., and Limmroth, V. (1999). Antimigraine drugs. Journal of Neurology 246 .
  58. Kaube, H., Knight, Y.E., Storer, R.J., Hoskin, K.L., May, A., and Goadsby, P.J. (1999). Vasodilator agents and supracollicular transection fail to inhibit cortical spreading depression in the cat. Cephalalgia 19 .
  59. Diener, H.-C., Kaube, H., and Limmroth, V. (1998). A practical guide to the management and prevention of migraine. Drugs 56 .
  60. May, A., Kaube, H., Büchel, C., Eichten, C., Rijntjes, M., Jüptner, M., Weiller, C., and Diener, H.C. (1998). Experimental cranial pain elicited by capsaicin: A PET study. Pain 74 .
  61. Scherbaum, N., Klein, S., Kaube, H., Kienbaum, P., Peters, J., and Gastpar, M. (1998). Alternative strategies of opiate detoxification: Evaluation of the so- called ultra-rapid detoxification. Pharmacopsychiatry 31 .
  62. Diener, H.-C., Gendolla, A., Jüptner, M., Kaube, H., and Limmroth, V. (1997). Emerging treatments in headache. European Neurology 38 .
  63. Kaube, H., and Diener, H.C. (1997). Differential diagnosis of acute attacks of migraine. Medizinische Klinik 92 .
  64. Hoskin, K.L., Kaube, H., and Goadsby, P.J. (1996). Sumatriptan can inhibit trigeminal afferents by an exclusively neural mechanism. Brain 119 .
  65. Kaube, H., and Limmroth, V. (1996). Animal models and their results in relation to the therapy of migraine. Schmerz 10 .
  66. Weiller, C., May, A., Limmroth, V., Juptner, M., Kaube, H., Schayck, R.V., Coenen, H.H., and Diener, H.C. (1995). Brain stem activation in spontaneous human migraine attacks. Nature Medicine 1 .
  67. Kaube, H., Hoskin, K.L., and Goadsby, P.J. (1994). Acetylsalicylic acid inhibits cerebral cortical vasodilatation caused by superior sagittal sinus stimulation in the cat. European Journal of Neurology 1 .
  68. Kaube, H., Hoskin, K.L., and Goadsby, P.J. (1993). Inhibition by sumatriptan of central trigeminal neurones only after blood‐brain barrier disruption. British Journal of Pharmacology 109 .
  69. Goadsby, P.J., Kaube, H., and Hoskin, K.L. (1992). Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Research 595 .
  70. Kaube, H., Hoskin, K.L., and Goadsby, P.J. (1992). Activation of the trigeminovascular system by mechanical distension of the superior sagittal sinus in the cat. Cephalalgia 12 .
  71. Pfaffenrath, V., Soyka, D., Kaube, H., Oestreich, W., and Haase, W. (1991). Flunarizine (20 mg) versus placebo in the treatment of migraine attacks with and without aura: Comprehensive results of multicentre double-blind studies. Nervenheilkunde 10 .
  72. Pfaffenrath, V., and Kaube, H. (1990). Diagnostics of cervicogenic headache. Functional Neurology 5 .
  73. Pfaffenrath, V., Niederberger, U., and Kaube, H. (1989). Studies on the predictive factors of treatment success in combination headache. Der Schmerz 3 .